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2,3-二氢苯并恶嗪[1,4]-3-酮的N-芳基哌嗪基衍生物的合成及降血脂活性

N-arylpiperazinyl derivatives of 2,3-dihydrobenzoxazin[1,4]-3-ones synthesis and normolipemic activity.

作者信息

Depreux P, Moussavi Z, Lesieur D, Sauzieres J

机构信息

Laboratoire de Chimie Therapeutique, Faculte des Sciences Pharmaceutiques et Biologiques, Lille, France.

出版信息

Farmaco. 1993 Aug;48(8):1079-89.

PMID:8216670
Abstract

Four series of N-arylpiperazinyl derivatives of the 7-substituted 2,3-dihydrobenzoxazin[1,4]-3-one were synthesized and preliminarily tested for hypolipemic activity. Substitutions in position 2 were performed. Hypotriglyceridemic activity was shown to be present in a number of compounds.

摘要

合成了7-取代的2,3-二氢苯并恶嗪并[1,4]-3-酮的四个系列的N-芳基哌嗪基衍生物，并对其降血脂活性进行了初步测试。进行了2位的取代。结果表明许多化合物具有降甘油三酯活性。

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