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抗真菌剂。VI. 顺式和反式-[2-(1,1'-联苯-4-基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲醇的卤代苯甲酰酯的体外抗真菌活性

Antifungal agents. VI. In vitro antifungal activities of halobenzoyl esters of cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3- dioxolan-4-yl]carbinols.

作者信息

Stefancich G, Silvestri R, Pagnozzi E, Artico M, Retico A, Apuzzo G, Simonetti N

机构信息

Dipartamento di Scienze Farmaceutiche, Università di Trieste, Italy.

出版信息

Farmaco. 1993 Aug;48(8):1103-12.

PMID:8216672
Abstract

The synthesis and the in vitro antifungal activities against Candida albicans and Candida spp of a number of halobenzoyl esters of cis- and trans- [2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4- yl]carbinols is reported. Some new imidazoles were found more active than ketoconazole and sometimes as potent as bifonazole against Candida albicans. All derivatives were found scarcely active against Candida spp.

摘要

报道了顺式和反式[2-(1,1'-联苯-4-基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲醇的多种卤代苯甲酰酯的合成及其对白色念珠菌和念珠菌属的体外抗真菌活性。发现一些新的咪唑类化合物比酮康唑更具活性，有时对白色念珠菌的活性与联苯苄唑相当。所有衍生物对念珠菌属几乎没有活性。

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