Pascalis L, Pia G, Aresu G, Frongia T, Barca L
Istituto di Patologia Speciale Medica I, Università degli Studi di Cagliari, Italy.
J Autoimmun. 1993 Aug;6(4):467-80. doi: 10.1006/jaut.1993.1039.
Thirty-two patients with endogenous uveitis resistant to treatment with high doses of cortisone and other immunosuppressive agents were treated with cyclosporin A (at an initial dose of 5 mg/kg/die, subsequently modified according to individual clinical response), fluocortolone and methotrexate. Total and lasting disease remission was obtained in all patients, together with the recovery of normal visual acuity in 20 cases and its significant improvement in the remaining 12. Furthermore, in all patients the total disappearance of all ocular inflammatory activity was observed and maintained for a period of 10.87 +/- 5.31 (6-18) months. No signs of renal or hepatic toxicity were observed in any of the patients. A form of hirsutism appeared in only two cases.
32例对大剂量皮质类固醇及其他免疫抑制剂治疗无效的内源性葡萄膜炎患者，接受了环孢素A（初始剂量为5mg/kg/天，随后根据个体临床反应调整）、氟可的龙和甲氨蝶呤治疗。所有患者均实现了疾病的完全且持久缓解，20例患者视力恢复正常，其余12例患者视力显著改善。此外，所有患者眼部炎症活动均完全消失，并持续了10.87±5.31（6 - 18）个月。所有患者均未观察到肾毒性或肝毒性迹象。仅2例患者出现多毛症。
