大鼠胃、小肠和胰腺联合移植后的排斥反应模式。
The pattern of rejection after combined stomach, small bowel, and pancreas transplantation in the rat.
作者信息
Oberhuber G, Schmid T, Thaler W, Klima G, Margreiter R
机构信息
Department of Transplant Surgery, University Hospital, University of Innsbruck, Austria.
出版信息
Transpl Int. 1993;6(5):296-8. doi: 10.1007/BF00336032.
This study was designed to investigate whether in combined stomach, small bowel, and pancreas transplantation allograft rejection occurs in the individual organs concomitantly and with the same intensity. Heterotopic en-bloc transplantation of the stomach, small bowel, and pancreas was performed in a Lewis-to-Brown Norway rat combination. Group 1 animals received no immunosuppressive therapy while animals in group 2 were treated with cyclosporin (10 mg/kg body weight, orally) daily. Grafts were histologically evaluated on the 5th (subgroups 1a and 2a) and 10th (subgroups 1b and 2b) postoperative days. The degree of rejection was defined as moderate, intermediate, or severe according to predefined criteria. The results indicate that the small bowel is more susceptible to rejection than either the stomach or the pancreas. Mucosal biopsies of the stomach are unlikely to provide a reliable guide to rejection in the small bowel.
本研究旨在调查在胃、小肠和胰腺联合移植中，各单个器官是否会同时且以相同强度发生同种异体移植排斥反应。采用Lewis大鼠与布朗挪威大鼠组合进行胃、小肠和胰腺的异位整块移植。第1组动物未接受免疫抑制治疗，而第2组动物每天接受环孢素（10mg/kg体重，口服）治疗。在术后第5天（1a和2a亚组）和第10天（1b和2b亚组）对移植物进行组织学评估。根据预先定义的标准，将排斥程度定义为中度、中度或重度。结果表明，小肠比胃或胰腺更容易发生排斥反应。胃黏膜活检不太可能为小肠排斥反应提供可靠的指导。
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