人β-珠蛋白基因5'侧翼序列中HMG蛋白（1 + 2）与负调控区1（NCR1）之间的相互作用。
Interaction between HMG proteins (1 + 2) and the negative regulatory region 1 (NCR1) in the 5'-flanking sequence of the human beta-globin gene.
作者信息
Qian R L, Chen Y D, Hu Y L, Li M Q, Wang Z H, Xu Y L
机构信息
Shanghai Institute of Cell Biology, Academia Sinica, PRC.
出版信息
Sci China B. 1993 Aug;36(8):933-9.
PMID:8216745
Abstract
The pattern of high mobility group proteins 1 and 2 (HMG1,2) interaction with the 5'-flanking sequence of the human beta-globin gene has been analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5'-flanking sequence of the human beta-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70 +/- 6 A) with a linear tail which seems to be a left-handed double helix structure.
摘要
已通过扫描隧道显微镜（STM）分析了高迁移率族蛋白1和2（HMG1,2）与人β-珠蛋白基因5'-侧翼序列的相互作用模式。人β-珠蛋白基因5'-侧翼序列中的一个200 bp负调控区域可被HMG蛋白1和2折叠成具有线性尾巴的环状结构（直径70 +/- 6 Å），该线性尾巴似乎是左手双螺旋结构。
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