人淋巴细胞质膜的细胞毒性活性。
Cytotoxic activity of human lymphocyte plasma membranes.
作者信息
Ferluga J, Friou G J, Allison A C
出版信息
Clin Exp Immunol. 1976 Aug;25(2):347-51.
Abstract
Plasma membrane fractions isolated from normal human peripheral blood lymphocytes have considerable cytolytic activity towards a cultured human lymphoblast cell line and mouse mastocytoma cells. Other subcellular fractions, including lysosomes, have low cytolytic activity. It is suggested that this cytotoxic potential in lymphocyte plasma membranes is normally latent but can be activated by prolonged and intimate contact with target cell plasma membranes.
摘要
从正常人外周血淋巴细胞中分离出的质膜组分对培养的人淋巴母细胞系和小鼠肥大细胞瘤细胞具有相当大的细胞溶解活性。其他亚细胞组分，包括溶酶体，细胞溶解活性较低。有人提出，淋巴细胞质膜中的这种细胞毒性潜能通常是潜伏的，但可通过与靶细胞质膜长时间紧密接触而被激活。
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An effector-cell independent step in target cell lysis by sensitized mouse lymphocytes.致敏小鼠淋巴细胞在靶细胞裂解过程中的效应细胞非依赖步骤。
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Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.细胞介导的细胞毒性、同种异体移植排斥反应和肿瘤免疫。
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