Filip V, Höschl C, Karen P, Seifertová D, Bornová L, Prasková H, Prasko J
Prague Psychiatric Centre, Czech Republic.
Br J Psychiatry Suppl. 1993 Sep(21):35-8.
We describe a double-blind study involving 58 in-patients with major depression (DSM-III). After one week on placebo, the patients were randomly assigned to either levoprotiline or maprotiline treatment for three weeks. In the next three weeks, responders were maintained on the same medication and non-responders were shifted to treatment with the complementary drug. After the initial three weeks' treatment, 31% of levoprotiline patients and 58% of maprotiline patients had responded. Both in the initial three-week period and after shifting non-responders to the complementary drug, there were significant differences in favour of maprotiline. The comparison of properties of different outcome criteria in prediction analyses shows that the final score gives the best agreement with global evaluation; using the delta score (final minus baseline) or ratio score (final/baseline) as the outcome criterion may yield paradoxical results.
我们描述了一项涉及58名重度抑郁症患者（DSM-III）的双盲研究。在服用安慰剂一周后，患者被随机分配接受左普替林或马普替林治疗三周。在接下来的三周里，有反应者继续使用相同药物，无反应者改用互补药物治疗。在最初三周的治疗后，31%的左普替林患者和58%的马普替林患者有反应。在最初的三周期间以及将无反应者改用互补药物后，马普替林均显示出显著优势。预测分析中不同结果标准属性的比较表明，最终评分与整体评估的一致性最佳；使用差值评分（最终评分减去基线评分）或比值评分（最终评分/基线评分）作为结果标准可能会产生矛盾的结果。
