Zwirner P, Murry T, Woodson G E
Ear, Nose and Throat Department, Georg August University, Göttingen, Germany.
Eur Arch Otorhinolaryngol. 1993;250(5):271-6. doi: 10.1007/BF00186224.
To assess the efficacy of bilateral or unilateral botulinum treatments for spasmodic dysphonia we injected botulinum toxin (type A) into the thyroarytenoid muscle of 24 patients with adductor type spasmodic dysphonia. Eleven patients underwent unilateral procedures and 13 bilateral procedures. Samples of sustained phonation were analyzed acoustically by a computer-assisted method and the air flow rates determined. All tests were conducted 1 week before injection and 1 week and 1 month after treatment. With unilateral injection, improvements in acoustic parameters occurred as early as 1 week after treatment. With bilateral injections, only the voice break factor was significantly reduced after 1 week, while standard deviations of fundamental frequency, jitter, shimmer and signal-to-noise-ratios were reduced 1 month after treatment. In comparison with unilateral injections, the mean air flow rate was twice as high 1 week after bilateral injections, with no significant differences found 1 month after treatment. Clinically, both injection modes resulted in the reduction of laryngeal spasms as early as within 48 h after injection.
为评估双侧或单侧肉毒杆菌治疗痉挛性发音障碍的疗效，我们对24例内收型痉挛性发音障碍患者的甲杓肌注射了A型肉毒杆菌毒素。11例患者接受单侧治疗，13例接受双侧治疗。通过计算机辅助方法对持续发声样本进行声学分析，并测定气流速率。所有测试均在注射前1周以及治疗后1周和1个月进行。单侧注射后，治疗后1周声学参数即出现改善。双侧注射时，仅在1周后嗓音破裂因子显著降低，而基频、抖动、闪烁和信噪比的标准差在治疗后1个月降低。与单侧注射相比，双侧注射后1周平均气流速率高出两倍，治疗后1个月未发现显著差异。临床上，两种注射方式均在注射后48小时内即可减轻喉部痉挛。
