Ionescu D A, Jipescu I, Haţegan D
Institute of Neurology and Psychiatry, Bucharest, Romania.
Rom J Neurol Psychiatry. 1993 Apr-Jun;31(2):105-10.
The local involvement of complement (C) in the pathophysiology of tissue lesions in several neurological diseases is known, but it has never been studied whether or not in neurological disorders the C activity in the circulation is altered as well. This was the aim of the present investigations. We measured in blood plasma, with an automatic device for analysis and quantitation of the haemolytic activity of the terminal complement complex, the variables T1, T2 and T3 which define the latter quantitatively. We did this, on the one hand, in 100 patients who had 46 neurological disorders systematized in 16 nosological groups, and, on the other hand, in a control group of 40 healthy blood-donors. The mean values of all variables found in the patients have not been statistically different from those found in the controls. This demonstrates that in neurological disorders possible activations of C remain restricted to the local tissue lesions and do not occur in blood, probably due to the opposition against C activation of the known inhibitor system.
补体（C）在几种神经疾病组织损伤病理生理学中的局部参与情况已为人所知，但在神经疾病中循环系统中的补体活性是否也会改变，此前从未有过研究。这就是本研究的目的。我们使用一种自动设备分析并定量末端补体复合物的溶血活性，以此来测定血浆中定义后者的变量T1、T2和T3。一方面，我们对100名患有46种神经疾病（归为16个病种组）的患者进行了检测，另一方面，对40名健康献血者组成的对照组进行了检测。患者组中所有变量的平均值与对照组相比，在统计学上并无差异。这表明在神经疾病中，补体可能的激活仍局限于局部组织损伤，而不会在血液中发生，这可能是由于已知的抑制系统对补体激活具有抵抗作用。
