Tamamori T, Nakayama F, Sugimoto H, Fenxiang J, Iwatsuki K, Takigawa M
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
Br J Dermatol. 1993 Oct;129(4):468-72. doi: 10.1111/j.1365-2133.1993.tb03180.x.
A 62-year-old woman had multiple plasmacytomas in the skin and lymph nodes, without Bence-Jones protein or a monoclonal peak of serum immunoglobulins. Infiltrating plasmacytoid cells expressed cytoplasmic IgG (lambda) and surface CD38, without any B-cell markers. There was no visceral or bone marrow involvement suggestive of multiple myeloma. Southern blot analysis of extracted DNA from the cutaneous lesions showed two rearranged bands with an immunoglobulin, but not a T-cell receptor, gene probe. The patient showed a poor response to chemotherapy, and died of bronchopneumonia. The clinical course and cytological features differentiate multiple cutaneous extramedullary plasmacytomas from solitary cutaneous extramedullary plasmacytoma and cutaneous lesions associated with multiple myeloma.
一名62岁女性在皮肤和淋巴结出现多发性浆细胞瘤，无本周氏蛋白或血清免疫球蛋白单克隆峰。浸润的浆细胞样细胞表达细胞质IgG（λ）和表面CD38，无任何B细胞标志物。无提示多发性骨髓瘤的内脏或骨髓受累情况。对皮肤病变提取的DNA进行Southern印迹分析，用免疫球蛋白而非T细胞受体基因探针显示出两条重排带。该患者对化疗反应不佳，死于支气管肺炎。临床病程和细胞学特征将多发性皮肤髓外浆细胞瘤与孤立性皮肤髓外浆细胞瘤以及与多发性骨髓瘤相关的皮肤病变区分开来。
