Bäck H, Jagenburg R, Rödjer S, Westin J
Department of Medicine, Ostra Hospital, Sweden.
Br J Haematol. 1993 Aug;84(4):746-8. doi: 10.1111/j.1365-2141.1993.tb03156.x.
Serum deoxythymidine kinase activity (S-TK) was determined in the diagnostic evaluation and follow-up of patients with monoclonal gammopathy of undetermined significance (MGUS). During a 4-year period 35 patients were included in the study. Normal concentrations of S-TK were found in 33. Patients with non-progressive monoclonal gammopathy kept a stable, and for the individual, a characteristic level of S-TK during several years of follow-up. A moderately elevated level of S-TK during observation did not indicate progression. Even in four out of five patients developing symptomatic multiple myeloma S-TK remained unchanged. Determination of S-TK does not give diagnostic or prognostic information in monoclonal gammopathy.
在意义未明的单克隆丙种球蛋白病（MGUS）患者的诊断评估及随访过程中，测定了血清脱氧胸苷激酶活性（S-TK）。在4年期间，35例患者纳入研究。33例患者的S-TK浓度正常。非进行性单克隆丙种球蛋白病患者在数年随访期间保持稳定且个体具有特征性的S-TK水平。观察期间S-TK轻度升高并不提示病情进展。即使在5例出现症状性多发性骨髓瘤的患者中，有4例S-TK仍无变化。测定S-TK在单克隆丙种球蛋白病中并不能提供诊断或预后信息。
