表睾酮对人睾丸中甾体17α-羟化酶和C17,20-裂解酶的抑制作用。
Inhibition of steroid 17 alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone.
作者信息
Bicíková M, Hampl R, Hill M, Stárka L
机构信息
Institute of Endocrinology, Prague, Czech Republic.
出版信息
J Steroid Biochem Mol Biol. 1993 Oct;46(4):515-8. doi: 10.1016/0960-0760(93)90106-7.
PMID:8217882
Abstract
Epitestosterone (17 alpha-hydroxy-4-androsten-3-one) inhibited competitively 17 alpha-hydroxylation of pregnenolone and subsequent C17,20-side chain cleavage of resulting 17 alpha-hydroxypregnenolone using microsomal preparations from the human testis. The inhibition constants for 17 alpha-hydroxylase and C17,20-lyase with 5-ene-precursors of C21-steroids were 96 and 12.4 mumol/l, respectively.
摘要
表睾酮（17α-羟基-4-雄烯-3-酮）使用人睾丸微粒体制剂竞争性抑制孕烯醇酮的17α-羟基化以及随后生成的17α-羟基孕烯醇酮的C17,20-侧链裂解。C21-甾体5-烯前体对17α-羟化酶和C17,20-裂解酶的抑制常数分别为96和12.4μmol/L。
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