Kunz J, Schmidt A
Institut für Pathologie des Klinikums, Ernst von Bergmann, Potsdam, Deutschland.
Zentralbl Pathol. 1993 Aug;139(3):201-5.
In 108 cases with benign breast lesions immunhistochemical studies using the monoclonal antibody Ki 67 yielded significantly lower values in comparison to 120 patients with breast carcinomas. The Ki 67 growth fraction showed a negative correlation with tumor size and nodal status and a positive correlation with tumor grading. The possible significance of this method performed on freeze sections in respect to the predictive estimation of nodal negative breast carcinomas and preneoplasias with indeterminate proliferative potential is emphasized.
在108例乳腺良性病变中，使用单克隆抗体Ki 67进行免疫组织化学研究，与120例乳腺癌患者相比，其值显著较低。Ki 67生长分数与肿瘤大小和淋巴结状态呈负相关，与肿瘤分级呈正相关。强调了这种在冰冻切片上进行的方法对于预测评估淋巴结阴性乳腺癌和具有不确定增殖潜能的癌前病变的可能意义。
