Christensen K, Fogh-Andersen P
Genetic Epidemiologic Research Unit, Odense University, Denmark.
Cleft Palate Craniofac J. 1993 Sep;30(5):469-74. doi: 10.1597/1545-1569_1993_030_0469_icpidm_2.3.co_2.
The etiology of most cases of isolated cleft palate (CP) is unknown. The relative importance of genes and environment can be studied using the classical twin method but only few and potentially highly selected CP twin data are available. The present CP twin study was based on four Danish nationwide ascertainment sources of CP multiple births in the period 1970-1990. The ascertainment sources covered the time period from 15 completed weeks of pregnancy to adolescence for the older cohorts. A total of 18 CP cases in multiple births were identified; two monozygotic twin pairs of which one was concordant and eight were dizygotic, discordant twin pairs. Three cases were from two triplet sets, and four discordant twin pairs were of unknown zygosity. The twin concordance rates suggest that genetic factors play a major role in the etiology of CP, but environmental and/or stochastic factors are probably acting as well.
大多数孤立性腭裂（CP）病例的病因尚不清楚。基因和环境的相对重要性可以通过经典的双胞胎方法进行研究，但仅有少量且可能经过高度筛选的CP双胞胎数据可用。本CP双胞胎研究基于丹麦1970年至1990年期间全国范围内的四个CP多胞胎确诊来源。确诊来源涵盖了较年长队列从妊娠15足周到青春期的时间段。共识别出18例多胞胎CP病例；两对单卵双胞胎，其中一对一致，八对双卵双胞胎，不一致。三例来自两个三胞胎组，四对不一致的双胞胎的合子性未知。双胞胎一致率表明，遗传因素在CP病因中起主要作用，但环境和/或随机因素可能也在起作用。
