新型多氟芳基叠氮化物与α-胰凝乳蛋白酶的合成及结合：用于光亲和标记的新型试剂
Synthesis and binding of new polyfluorinated aryl azides to alpha-chymotrypsin. New reagents for photoaffinity labeling.
作者信息
Soundararajan N, Liu S H, Soundararajan S, Platz M S
机构信息
Department of Chemistry, Ohio State University, Columbus 43210.
出版信息
Bioconjug Chem. 1993 Jul-Aug;4(4):256-61. doi: 10.1021/bc00022a002.
PMID:8218481
Abstract
The preparation of several new, water-soluble, polyfluorinated aryl azide reagents for use in photoaffinity labeling studies is described. The ability of some of these reagents and their nonfluorinated controls to noncovalently bind to alpha-chrymotrypsin is reported. It is found that polyfluorination does not interfere with ligand binding.
摘要
本文描述了几种用于光亲和标记研究的新型水溶性多氟芳基叠氮化物试剂的制备方法。报道了其中一些试剂及其非氟化对照物与α-胰凝乳蛋白酶非共价结合的能力。研究发现多氟化不会干扰配体结合。
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