Ershler W B, Sun W H, Binkley N, Gravenstein S, Volk M J, Kamoske G, Klopp R G, Roecker E B, Daynes R A, Weindruch R
Department of Medicine, University of Wisconsin-Madison.
Lymphokine Cytokine Res. 1993 Aug;12(4):225-30.
Interleukin-6 (IL-6) is a multifunctional cytokine that is proving to be a major contributor to the acute phase inflammatory response. IL-6 expression is normally low and serum levels are usually nondetectable in the absence of inflammation. With advancing age, however, serum levels become detectable and it is proposed that this reflects an age-associated loss in the normal regulation of gene expression for this molecule. There is also speculation that IL-6 may contribute to the pathogenesis of several diseases that are common in late-life including lymphoma, osteoporosis, and Alzheimer's disease. In this report we demonstrate that plasma levels of IL-6 rise with advancing age in well-selected healthy elderly people and comparably in old rhesus monkeys. That this change reflects a primary aging process is suggested by our findings in C57BL/6 mice in which the age-associated increase in the in vitro synthesis of IL-6 is largely prevented by life span-extending dietary restriction.
白细胞介素-6（IL-6）是一种多功能细胞因子，已被证明是急性期炎症反应的主要促成因素。在没有炎症的情况下，IL-6的表达通常较低，血清水平通常检测不到。然而，随着年龄的增长，血清水平变得可检测到，有人提出这反映了该分子基因表达正常调节中与年龄相关的丧失。也有推测认为，IL-6可能促成几种老年常见疾病的发病机制，包括淋巴瘤、骨质疏松症和阿尔茨海默病。在本报告中，我们证明，在精心挑选的健康老年人以及老年恒河猴中，IL-6的血浆水平随着年龄的增长而升高。我们在C57BL/6小鼠中的发现表明，这种变化反映了一个原发性衰老过程，在这些小鼠中，通过延长寿命的饮食限制，很大程度上阻止了与年龄相关的IL-6体外合成增加。
