Bodjarian N, Carpentier P, Blanchet G, Baubichon D, Lallement G
Unité de Neurotoxicologie, Centre de Recherches du Service de Santé des Armées, La Tronche, France.
Neuroreport. 1993 Sep 3;4(10):1191-3.
In the present study we investigated the role of the cholinergic pathway in phosphoinositide metabolism activation observed during soman-induced convulsions. We thus studied the effect of atropine sulphate, a muscarinic antagonist (20 mg kg-1, i.p.), on IP3 levels in rat hippocampus. We demonstrated that initially, the increase of IP3 is closely seizure-related. On the other hand, after 10 min of seizures, the IP3 enhancement and the seizure activity are no longer correlated. After 20 min of seizures, atropine failed to inhibit soman-induced IP3 enhancement, suggesting that the activation of another neurotransmitter system(s) linked to PPI turnover succeeds the cholinergic stimulation.
在本研究中，我们调查了胆碱能通路在梭曼诱导惊厥期间观察到的磷酸肌醇代谢激活中的作用。因此，我们研究了毒蕈碱拮抗剂硫酸阿托品（20 mg/kg，腹腔注射）对大鼠海马中肌醇-1,4,5-三磷酸（IP3）水平的影响。我们证明，最初，IP3的增加与癫痫发作密切相关。另一方面，癫痫发作10分钟后，IP3的增强与癫痫活动不再相关。癫痫发作20分钟后，阿托品未能抑制梭曼诱导的IP3增强，这表明与磷酸肌醇代谢周转相关的另一种神经递质系统的激活在胆碱能刺激之后发生。
