Friede J D, Henderson L M
J Bacteriol. 1976 Sep;127(3):1239-47. doi: 10.1128/jb.127.3.1239-1247.1976.
Hydroxylysine is metabolized via two routes by a Pseudomonas fluorescens strain as shown by the oxidation of selected intermediates. Hydroxy-L-lysine is oxidized via a pathway analogous to the monooxygenase pathway for L-lysine, and data suggest that at least some of tthe enzymes are those involved in the metabolism of L-lysine. Hydroxy-L-lysine is also converted by a racemase to allohydroxy-D-lysine, which is then degraded via a pathway analogous to, but different from, that described for D-lysine, involving hydroxy-L-pipecolate, 2-amino-5-hydroxyadipate, and 2-hydroxyglutarate. Data obtained with mutants unable to oxidize L-pipecolate suggest that the enzymes for the metabolism of hydroxy-L-pipecolate are distinct from those for L-pipecolate. Studies on D- and L-lysine degradation have shown that the previously described pathways for these compounds are present in this soil pseudomonad.
如选定中间体的氧化所示，荧光假单胞菌菌株通过两条途径代谢羟赖氨酸。羟-L-赖氨酸通过类似于L-赖氨酸单加氧酶途径的途径被氧化，数据表明至少一些酶参与L-赖氨酸的代谢。羟-L-赖氨酸也被消旋酶转化为别羟-D-赖氨酸，然后通过类似于但不同于描述的D-赖氨酸途径的途径降解，该途径涉及羟-L-哌啶酸、2-氨基-5-羟基己二酸和2-羟基戊二酸。用不能氧化L-哌啶酸的突变体获得的数据表明，羟-L-哌啶酸代谢的酶与L-哌啶酸代谢的酶不同。对D-和L-赖氨酸降解的研究表明，先前描述的这些化合物的途径存在于这种土壤假单胞菌中。
