Svensson P, Bjerring P, Arendt-Nielsen L, Kaaber S
Department of Prosthetic Dentistry, Royal Dental College, Aarhus University, Denmark.
Clin J Pain. 1993 Sep;9(3):207-15. doi: 10.1097/00002508-199309000-00009.
Psychophysical assessments of orofacial sensory function were performed in order to investigate neurophysiological aspects of the burning mouth syndrome (BMS).
Sensory and pain thresholds to brief argon laser stimulation were determined on six test regions, which included the tip of tongue, the lower lip mucosa and skin, the buccal mucosa, the anterior hard palate, and the dorsum of the hand.
The experimental examination was performed at the Pain Clinic Unit at the Royal Dental College.
Twenty-three elderly denture-wearing patients diagnosed as suffering from BMS were studied, and a control group included 23 age-, sex-, and denture-matched subjects. The obtained thresholds were compared between groups.
Sensory thresholds were significantly higher and ratios between pain and sensory thresholds significantly lower in patients with BMS on all the tested regions. Pain thresholds were significantly elevated on the lower lip skin, the anterior hard palate, and the hand in patients with BMS. At sensory threshold level, a faint pinprick perception was often reported by patients with BMS contrary to a perception of warmth described by control subjects. The intraregional variations in sensory and pain thresholds on the hard palate, the lower lip mucosa, and on the skin were similar in both groups, but differences occurred in sensory thresholds on the tongue in patients with BMS.
The presence of abnormal prepain perceptions and disturbances in the perception of nonnociceptive and nociceptive thermal stimuli applied on both pain-affected and normal regions suggest a perceptual deficit unrelated to specific pathophysiological mechanisms in BMS. However, it appears that a psychological explanation of BMS should be used cautiously, as the present results suggest alterations in sensory function.
进行口面部感觉功能的心理物理学评估，以研究灼口综合征（BMS）的神经生理学方面。
在六个测试区域测定对短暂氩激光刺激的感觉和疼痛阈值，这些区域包括舌尖、下唇黏膜和皮肤、颊黏膜、硬腭前部以及手背。
实验检查在皇家牙科学院疼痛诊所进行。
研究了23名被诊断患有BMS的戴假牙老年患者，对照组包括23名年龄、性别和假牙匹配的受试者。比较两组获得的阈值。
在所有测试区域，BMS患者的感觉阈值显著更高，疼痛与感觉阈值的比率显著更低。BMS患者在下唇皮肤、硬腭前部和手部的疼痛阈值显著升高。在感觉阈值水平，BMS患者常报告有轻微的针刺感，而对照组受试者则描述为有温热感。两组在硬腭、下唇黏膜和皮肤上的感觉和疼痛阈值的区域内变化相似，但BMS患者在舌部的感觉阈值存在差异。
在疼痛受影响区域和正常区域施加的非伤害性和伤害性热刺激的预疼痛感知异常和感知障碍表明，BMS中存在与特定病理生理机制无关的感知缺陷。然而，由于目前的结果表明感觉功能发生了改变，因此对BMS的心理学解释应谨慎使用。
