Schweitzer D, Augsten R, Scibor M, Königsdörffer E, Hammer M
Universitäts-Augenklinik Jena.
Ophthalmologe. 1993 Oct;90(5):452-6.
An order to optimize photocoagulation in diabetic retinopathy, it is necessary to have objective criteria concerning substance-specific fundus changes like blood, melanin, xanthophyl, cytochrome aa3, and light scattering. By means of fundus reflectometry macular reflectance spectra can be measured and are different in normals and in diabetics before or after treatment. If logarithmic difference spectra are used only pathological alterations or changes caused by the coagulation are demonstrable. These difference spectra can be approximated by a linear model function containing the extinction spectra of the substances mentioned above and a term for light scattering. Spectra deconvolution delivers coefficients, describing differences in the substance concentrations between diabetics before and after treatment and age-matched normals. When we examined these coefficients, we found that neither their behavior in diabetic retinopathy nor their reaction to photocoagulation is unique. Thus, it might be possible to obtain references to patient-specific adapted coagulation by deconvolution of the macular reflectance spectra measured before treatment. Classification of the patients in specific types of reaction, according to the shape of the logarithmic difference spectra or the results of the spectra deconvolution, could be a step in deciding on the success of the therapy on a case-to-case basis.
为了优化糖尿病视网膜病变的光凝治疗，有必要制定关于特定物质眼底变化的客观标准，如血液、黑色素、叶黄素、细胞色素aa3和光散射。通过眼底反射测量法可以测量黄斑反射光谱，其在正常人和糖尿病患者治疗前后有所不同。如果使用对数差光谱，仅能显示病理改变或由光凝引起的变化。这些差光谱可以用一个线性模型函数来近似，该函数包含上述物质的消光光谱和一个光散射项。光谱去卷积可得出系数，描述糖尿病患者治疗前后以及年龄匹配的正常人之间物质浓度的差异。当我们检查这些系数时，发现它们在糖尿病视网膜病变中的表现及其对光凝治疗的反应都不是唯一的。因此，通过对治疗前测量的黄斑反射光谱进行去卷积，有可能获得针对患者个体的适应性光凝参考。根据对数差光谱的形状或光谱去卷积的结果，将患者分类为特定类型的反应，可能是逐案确定治疗成功与否的一个步骤。
