Berninger T A, Polkinghorne P J, Capon M R, Arden G B, Bird A C
Augenklinik, Universität München.
Ophthalmologe. 1993 Oct;90(5):515-8.
In 34 asymptomatic patients from three families at 50% risk of developing Sorsby's fundus dystrophy, colour contrast sensitivity was measured. In 16 the thresholds--mainly of the tritan axis--were raised above the normal values. It is concluded that testing of colour vision is useful in detecting the abnormal genotype. Raised colour contrast sensitivity was not observed before the first fundus or fluorescein angiographic changes in two of the families, while the colour defect occurred in the absence of ophthalmoscopic abnormality in the third family. Therefore, our results support the clinical suggestion that Sorsby's fundus dystrophy is more than one disease.
在三个家族中患索斯比眼底营养不良风险为50%的34名无症状患者中，测量了颜色对比敏感度。其中16名患者的阈值（主要是蓝黄色轴的阈值）高于正常值。得出的结论是，色觉测试有助于检测异常基因型。在其中两个家族中，在首次出现眼底或荧光素血管造影改变之前未观察到颜色对比敏感度升高，而在第三个家族中，在没有眼底镜异常的情况下出现了色觉缺陷。因此，我们的结果支持了临床观点，即索斯比眼底营养不良不止一种疾病。
