Edward M, MacKie R M
University of Glasgow, Department of Dermatology, UK.
Melanoma Res. 1993 Aug;3(4):227-34.
Although great advances have been made in recent years in understanding the interactions between tumour cells and their environment, we still do not fully understand the complex mechanisms involved in the steps by which in situ malignancy becomes invasive and then metastatic. To complete the various steps of the pathway to metastatic malignancy, melanoma cells have acquired the ability to grow in the absence of certain growth factors while producing autocrine factors. They are also able to modulate the extracellular matrix and express an array of adhesion molecules enabling them to interact with various cell types and extracellular matrix molecules during the establishment of secondary tumours.
尽管近年来在理解肿瘤细胞与其环境之间的相互作用方面取得了巨大进展，但我们仍未完全了解原位恶性肿瘤转变为侵袭性进而转移性肿瘤所涉及的复杂机制。为了完成转移性恶性肿瘤途径的各个步骤，黑色素瘤细胞已经获得了在缺乏某些生长因子的情况下生长同时产生自分泌因子的能力。它们还能够调节细胞外基质并表达一系列粘附分子，使其在继发性肿瘤形成过程中能够与各种细胞类型和细胞外基质分子相互作用。
