Saiki I
Section of Chemistry, Hokkaido University.
Gan To Kagaku Ryoho. 1993 Feb;20(3):363-72.
Since the establishment of an experimental metastasis model using some tumor metastatic cell lines, progress has been made in basic studies on tumor metastasis. In addition, the complex mechanisms of tumor metastasis have been elucidated by the cellular and molecular studies. Here we focus our attention on the relationship between tumor metastasis and cellular adhesiveness, a factor which is a critical determinant in tumor progression and metastasis. The roles of cell adhesive molecules in the metastatic process are also described. This type of study is invaluable in understanding the molecular and regulatory mechanisms of tumor metastasis. We also report the antimetastatic effect of some polypeptides of fibronectin in the extracellular matrices, poly (RGD) and recombinant fusion peptide containing cell- and heparin-binding domain of fibronectin (CH-271) in regulating the mechanism of tumor cell adhesion.
自从利用某些肿瘤转移细胞系建立实验性转移模型以来，肿瘤转移的基础研究取得了进展。此外，通过细胞和分子研究阐明了肿瘤转移的复杂机制。在此，我们将注意力集中在肿瘤转移与细胞黏附性之间的关系上，细胞黏附性是肿瘤进展和转移的关键决定因素。还描述了细胞黏附分子在转移过程中的作用。这类研究对于理解肿瘤转移的分子和调节机制非常重要。我们还报告了细胞外基质中纤连蛋白的某些多肽、聚（RGD）以及含有纤连蛋白细胞结合和肝素结合结构域的重组融合肽（CH-271）在调节肿瘤细胞黏附机制方面的抗转移作用。
