重组人粒细胞巨噬细胞集落刺激因子对急性髓性白血病患者髓系克隆形成细胞的影响。
Effects of rhGM-CSF on myeloid clonogenic cells in acute myelogenous leukemia patients.
作者信息
Preisler H, Larson R, Banavali S, Yin M, Li Y Q, Banerjee M, Gopal V, Raza A
机构信息
University of Cincinnati Medical Center, Ohio 45267-0508.
出版信息
Leuk Lymphoma. 1993 Jun;10(3):183-6. doi: 10.3109/10428199309145881.
The effects of rhGM-CSF in vivo on the myeloid clonogenic cells present in 6 AML patients was evaluated. The relative number of clonogenic cells fell in 4 of the 6 patients. The effects of rhGM-CSF on the percentage of clonogenic cells in S phase and the sensitivity of clonogenic cells to cytosine arabinoside varied among the patients. These effects were not related to the effects of rhGM-CSF on the white blood cell count or on the proliferative rate of the leukemia cell population as a whole.
评估了重组人粒细胞巨噬细胞集落刺激因子（rhGM-CSF）在体内对6例急性髓系白血病（AML）患者髓系克隆形成细胞的影响。6例患者中有4例克隆形成细胞的相对数量下降。rhGM-CSF对处于S期的克隆形成细胞百分比的影响以及克隆形成细胞对阿糖胞苷的敏感性在患者之间存在差异。这些影响与rhGM-CSF对白细胞计数或整个白血病细胞群体增殖率的影响无关。
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