Miwa T, Nakao K, Takahashi M, Kaneto H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Biol Pharm Bull. 1993 Aug;16(8):806-7. doi: 10.1248/bpb.16.806.
Intraperitoneal administration of lauric acid (C12) at the high doses, 100-1000 mumol/kg, showed weak but dose-dependent antinociceptive effect in mice. Pretreatment of the animals with 0.1 mumol/kg of i.p. C12 tended to suppress the antinociceptive effect of 7 mg/kg of s.c. morphine and daily combination of this dose of C12 with 10 mg/kg of s.c. morphine blocked the development of antinociceptive tolerance to morphine. However, increasing or decreasing of the dose of C12 resulted in the loss of its modulatory effect on morphine. The strict dose-dependency of C12 in its action on morphine suggests that there is a regulatory role for C12, a medium length straight chain fatty acid, in the endogenous pain inhibitory system.
以100 - 1000 μmol/kg的高剂量腹腔注射月桂酸（C12），在小鼠中显示出微弱但剂量依赖性的镇痛作用。用0.1 μmol/kg腹腔注射C12预处理动物，倾向于抑制7 mg/kg皮下注射吗啡的镇痛作用，并且该剂量的C12与10 mg/kg皮下注射吗啡的每日联合用药可阻断对吗啡镇痛耐受性的发展。然而，C12剂量的增加或减少都会导致其对吗啡调节作用的丧失。C12对吗啡作用的严格剂量依赖性表明，中等长度直链脂肪酸C12在内源性疼痛抑制系统中具有调节作用。
