Adu D, Berisa F, Howie A J, Emery P, Bacon P A, McConkey B, McGonigle R J, Michaels J, Popert A J
Queen Elizabeth Hospital, Edgbaston, Birmingham.
Br J Rheumatol. 1993 Nov;32(11):1008-11. doi: 10.1093/rheumatology/32.11.1008.
We present data on 10 patients with RA who developed glomerulonephritis which was not related to gold or penicillamine therapy. Although two of these patients had received gold this had been discontinued 13 and 18 yr before the diagnosis of glomerulonephritis. Seven patients presented with nephrotic syndrome and three with proteinuria and microscopic haematuria. Renal histology showed a membranous nephropathy (five patients), mesangial IgA nephropathy (two patients), focal segmental necrotizing glomerulonephritis (two patients) and focal segmental glomerulosclerosis (one patient).
我们报告了10例类风湿关节炎(RA)患者的数据,这些患者发生了与金制剂或青霉胺治疗无关的肾小球肾炎。尽管其中2例患者曾接受过金制剂治疗,但在肾小球肾炎诊断前13年和18年就已停用。7例患者表现为肾病综合征,3例表现为蛋白尿和镜下血尿。肾脏组织学检查显示为膜性肾病(5例)、系膜IgA肾病(2例)、局灶节段性坏死性肾小球肾炎(2例)和局灶节段性肾小球硬化(1例)。