通过荧光原位杂交将15个黏粒定位到人类22号染色体上。

Localization of 15 cosmids on human chromosome 22 by fluorescence in situ hybridization.

作者信息

Lévy N, Lamour V, Danglot G, Slim R, Lipinski M, Bernheim A

机构信息

CNRS URA 1158, Laboratoire de Cytogénétique et Génétique Oncologiques, Institut Gustave-Roussy, Villejuif, France.

出版信息

C R Acad Sci III. 1993;316(5):482-6.

PMID:8221231

Abstract

Fluorescence in situ hybridization has been used in a cytogenetic analysis to map 15 cosmids on human chromosome 22. Thirteen cosmids were localized on the long arm of chromosome 22 (22q) while two other probes displayed a hybridization signal on 22p and the short arm of the acrocentric chromosomes of groups D and G. The regional assignment of these new chromosome markers will improve the mapping of chromosome 22; they can be used to detect numerical and structural aberrations of this chromosome involved in numerous pathologies.

摘要

荧光原位杂交已用于细胞遗传学分析，以将15个黏粒定位到人类22号染色体上。13个黏粒定位于22号染色体长臂（22q），而另外两个探针在22p以及D组和G组近端着丝粒染色体短臂上显示杂交信号。这些新的染色体标记物的区域定位将改善22号染色体的图谱绘制；它们可用于检测涉及多种病理学的该染色体的数目和结构异常。