CMAJ. 1993 Oct 15;149(8):1132-7.
The following recommendations on pertussis vaccine from the National Advisory Committee on Immunization will appear in the fourth edition of the Canadian Immunization Guide, scheduled for publication in autumn 1993. These revised recommendations represent a major change in vaccine usage and take account of the current understanding of adverse events associated with use of pertussis vaccine. Most adverse events are no longer contraindications to further immunization; only anaphylactic reaction to a previous dose remains an absolute contraindication to pertussis immunization. Other adverse reactions for which there are no sequelae or that have not been proven to be caused by the vaccine are no longer considered valid reasons for withholding immunization. It is hoped that simplification of the contraindications will improve vaccine utilization and achieve higher levels of age-appropriate immunization.
国家免疫咨询委员会关于百日咳疫苗的下列建议将出现在定于1993年秋季出版的《加拿大免疫指南》第四版中。这些修订后的建议代表了疫苗使用方面的重大变化,并考虑到了目前对与使用百日咳疫苗相关的不良事件的认识。大多数不良事件不再是进一步免疫接种的禁忌证;只有对先前剂量出现过敏反应仍然是百日咳免疫接种的绝对禁忌证。没有后遗症或未被证明是由疫苗引起的其他不良反应,不再被视为拒绝免疫接种的正当理由。希望简化禁忌证将提高疫苗利用率,并实现更高水平的适龄免疫接种。