Cortessis V, Ingles S, Millikan R, Diep A, Gatti R A, Richardson L, Thompson W D, Paganini-Hill A, Sparkes R S, Haile R W
Department of Epidemiology, University of California, Los Angeles 90024-1772.
Cancer Res. 1993 Nov 1;53(21):5083-6.
Recent reports suggest that subjects who are heterozygous for the ataxia-telangiectasia gene are at increased risk of breast cancer. We conducted linkage analyses of 64 families with premenopausal bilateral breast cancer using DRD2, a marker linked to the ataxia-telangiectasia locus at 11q22-23. We assumed a model with dominant transmission of breast cancer. Lod scores summed over all families provided strong evidence against tight linkage (e.g., a lod score of -6.08 at theta = 0.00001), although a single family provides suggestive evidence of tight linkage to DRD2. Evidence against linkage to 11q was strongest among families that may involve the BRCA1 breast cancer susceptibility gene on 17q21. However, we did not observe evidence of linkage to 11q among the remaining subgroup with neither a family history of ovarian cancer nor the appearance of linkage to 17q21.
最近的报告表明，共济失调毛细血管扩张症基因杂合的受试者患乳腺癌的风险增加。我们使用DRD2（一种与位于11q22 - 23的共济失调毛细血管扩张症基因座连锁的标记）对64个绝经前双侧乳腺癌家庭进行了连锁分析。我们假设乳腺癌为显性遗传模式。尽管单个家庭提供了与DRD2紧密连锁的提示性证据，但对所有家庭的Lod分数求和提供了反对紧密连锁的有力证据（例如，在θ = 0.00001时Lod分数为 - 6.08）。在可能涉及位于17q21的BRCA1乳腺癌易感基因的家庭中，反对与11q连锁的证据最为强烈。然而，在既无卵巢癌家族史也无与17q21连锁迹象的其余亚组中，我们未观察到与11q连锁的证据。
