精氨酸加压素和甲状旁腺激素相关蛋白对绵羊胎儿肾功能的影响。
Effect of arginine vasopressin and parathyroid hormone-related protein on renal function in the ovine foetus.
作者信息
Horne R S, MacIsaac R J, Moritz K M, Tangalakis K, Wintour E M
机构信息
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
出版信息
Clin Exp Pharmacol Physiol. 1993 Sep;20(9):569-77. doi: 10.1111/j.1440-1681.1993.tb01743.x.
Abstract
- The effects of intravenous infusions of arginine vasopressin (AVP), parathyroid hormone-related protein (PTHrP) and AVP+PTHrP on renal function in intact ovine foetuses at 100-125 days of gestation were examined. 2. A low dose of AVP (5.5 +/- 0.9 pmol/h) increased plasma AVP concentrations from 0.6 pmol/L to 2.1 +/- 0.4 pmol/L (mean +/- s.e.m; n = 8). This dose caused a significant reduction in free water clearance (CH2O; P < 0.001), without any significant change in fetal arterial blood pressure, glomerular filtration rate (GFR), or the urinary excretion rates of sodium, calcium or 3',5'-cyclic adenosine monophosphate (cAMP). 3. Infusions of PTHrP (1 nmol/h), with or without 1 nmol bolus dose, significantly increased (P < 0.05) urine osmolality (UOSM), but did not synergize with AVP in reducing CH2O. 4. It is concluded that AVP and PTHrP do not act synergistically on the kidney of the intact ovine foetus.
摘要
- 研究了妊娠100 - 125天的完整绵羊胎儿静脉输注精氨酸加压素（AVP）、甲状旁腺激素相关蛋白（PTHrP）以及AVP + PTHrP对肾功能的影响。2. 低剂量的AVP（5.5±0.9 pmol/h）使血浆AVP浓度从0.6 pmol/L升高至2.1±0.4 pmol/L（均值±标准误；n = 8）。该剂量导致自由水清除率（CH2O）显著降低（P < 0.001），而胎儿动脉血压、肾小球滤过率（GFR）以及钠、钙或3',5'-环磷酸腺苷（cAMP）的尿排泄率均无显著变化。3. 输注PTHrP（1 nmol/h），无论有无1 nmol的推注剂量，均显著升高（P < 0.05）尿渗透压（UOSM），但在降低CH2O方面未与AVP产生协同作用。4. 得出的结论是，AVP和PTHrP对完整绵羊胎儿的肾脏没有协同作用。
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