Shaked Y, Blau A, Shpilberg O, Samra Y
Rusinow Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Clin Nephrol. 1993 Aug;40(2):79-82.
Hyporeninemic hypoaldosteronism is an important underlying condition, causing hyperkalemia with hyperchloremic metabolic acidosis, disproportionate to the degree of renal insufficiency present. The principal defect in this syndrome is a reduced level of plasma renin activity, which results in secondary hypoaldosteronism. Diabetes mellitus is usually the primary underlying renal disease, though other causes of renal diseases associated with this syndrome have been described. This case report describes for the first time an elderly patient with multiple myeloma, in remission for more than 11 years, associated with the syndrome of hyporeninemic hypoaldosteronism at the time of diagnosis. The complete resolution of the syndrome after vigorous chemotherapy is an intriguing possibility.
低肾素性低醛固酮血症是一种重要的潜在病症，可导致高钾血症伴高氯性代谢性酸中毒，其程度与现存肾功能不全程度不相称。该综合征的主要缺陷是血浆肾素活性水平降低，从而导致继发性低醛固酮血症。糖尿病通常是主要的潜在肾脏疾病，不过也有其他与该综合征相关的肾脏疾病病因的报道。本病例报告首次描述了一名老年患者，其多发性骨髓瘤已缓解超过11年，在诊断时伴有低肾素性低醛固酮血症综合征。积极化疗后该综合征完全缓解是一种引人关注的可能性。
