Refetoff S
Department of Medicine, University of Chicago, Illinois.
Clin Lab Med. 1993 Sep;13(3):563-81.
Resistance to thyroid hormone encompasses a clinically heterogeneous group of conditions characterized by reduced responses of target tissues to a supply of thyroid hormone that under normal circumstances would be excessive. The syndrome of resistance to thyroid hormone is first suspected when serum thyroid hormone levels are found to be elevated in the presence of nonsuppressed serum thyrotropin (TSH). Clinical confirmation of the diagnosis requires the demonstration of the failure of full replacement doses of thyroid hormone to produce the expected suppressive effect on the secretion of TSH and a failure to induce appropriate responses in peripheral tissues.
甲状腺激素抵抗包括一组临床异质性疾病，其特征是在正常情况下过量的甲状腺激素供应下，靶组织的反应降低。当在未被抑制的血清促甲状腺激素（TSH）存在的情况下发现血清甲状腺激素水平升高时，首先怀疑甲状腺激素抵抗综合征。该诊断的临床确认需要证明全量替代剂量的甲状腺激素未能对TSH分泌产生预期的抑制作用，以及未能在外周组织中诱导适当的反应。
