艾滋病患者卡氏肺孢子虫肺炎复发的预防。小剂量磺胺甲恶唑-甲氧苄啶的疗效与耐受性。
Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.
作者信息
Nielsen T L, Jensen B N, Nelsing S, Pedersen C, Mathiesen L R, Skinhøj P, Nielsen J O
机构信息
Department of Infectious Diseases, Hvidovre Hospital, Copenhagen.
出版信息
Dan Med Bull. 1993 Sep;40(4):503-5.
The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1% (95% CI 0.0%-11.0%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5%) (95% CI 2.1%-9.3%).
对166例艾滋病患者进行回顾性评估，以400mg/80mg剂量的复方磺胺甲恶唑（SMX-TMP）每日两次作为预防卡氏肺孢子虫肺炎（PCP）的二线预防用药（SP）的有效性和耐受性。平均观察期为9.7个月（范围1.0 - 1.4年）。8例患者发生PCP复发；4例经组织学证实，4例为临床推测。使用对数秩检验，预防一年后的复发率为5.1%（95%可信区间0.0% - 11.0%）。8例患者（5%）（95%可信区间2.1% - 9.3%）报告了二线预防不耐受情况，定义为因不良反应而必须停用SMX-TMP进行二线预防。
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