果蝇中的核苷营养缺陷型：一个常染色体位点产生可被嘌呤和嘧啶核糖核苷补充的突变体。
Nucleoside auxotrophy in Drosophila: an autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides.
作者信息
Naguib F N, Nash D
出版信息
Mol Gen Genet. 1976 Aug 10;147(1):13-21. doi: 10.1007/BF00337930.
PMID:822279
Abstract
Two allelic auxotrophic mutants at a locus close to the bw locus (2-104.5) of Drosophila melanogaster are described. The mutants respond to dietary ribonucleosides (uridine, cytidine, adenosine, guanosine and inosine) but less well to bases or pyrimidine precursors. This phenotype is unique to these mutants. We suggest that the mutants are defective in phosphoribosyl pyrophosphate biosynthesis.
摘要
描述了黑腹果蝇中与bw基因座（2-104.5）接近的一个位点上的两个等位营养缺陷型突变体。这些突变体对膳食核糖核苷（尿苷、胞苷、腺苷、鸟苷和肌苷）有反应，但对碱基或嘧啶前体的反应较差。这种表型是这些突变体所特有的。我们认为这些突变体在磷酸核糖焦磷酸生物合成方面存在缺陷。
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