al-Gharably N M, Osman A M, al-Shabanah O A, al-Bekairi A M, al-Harbi M M
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Chemotherapy. 1993 Nov-Dec;39(6):410-5. doi: 10.1159/000238986.
The calcium channel blocker verapamil increased the intracellular level of doxorubicin in Ehrlich ascites cells. The high cellular drug level was directly related to the enhancement of the cytotoxicity of the antitumor agent. Tumor-bearing mice pretreated with verapamil showed a 2.3-fold increase in long-term survival effect of doxorubicin together with a pronounced inhibitory effect on tumor DNA, RNA and protein content. This study suggests the possible novel use of verapamil to enhance the antitumor activity of doxorubicin, allowing its dose, and consequently the serious side effects, to be reduced.
钙通道阻滞剂维拉帕米可提高艾氏腹水癌细胞内阿霉素的水平。细胞内药物水平升高与抗肿瘤药物细胞毒性的增强直接相关。用维拉帕米预处理的荷瘤小鼠，阿霉素的长期生存效应提高了2.3倍，同时对肿瘤DNA、RNA和蛋白质含量有明显的抑制作用。本研究提示维拉帕米可能具有新的用途，即增强阿霉素的抗肿瘤活性，从而降低其用药剂量及严重的副作用。
