脂蛋白(a)升高作为心脑血管疾病的独立危险因素。

Increased lipoprotein (a) as an independent risk factor for cardiovascular and cerebrovascular diseases.

作者信息

Zhuang Y Y, Wang J J, Xu P

机构信息

Department of Biochemistry, Nanjing Jinling Hospital, Medical Institute of Nanjing University.

出版信息

Chin Med J (Engl). 1993 Aug;106(8):597-600.

PMID:8222908

Abstract

We quantified serum lipoprotein(a) [Lp(a)] in 1266 healthy persons and established the reference value of Lp(a) in groups of age and sex. The Lp(a) in myocardial infarction (MI) survivors, stroke and primary hypertension patients were determined in comparison with that of age-matched normal controls. Moreover, cholesterol, triglyceride, HDL-cholesterol, apo Al and apo B were measured. The Lp(a) concentrations were not correlated with other lipids in normal controls and patients. Our results suggest that increased Lp(a) is an independent risk factor for MI and stroke patients. The total detective rate of abnormal lipids in MI and stroke patients was as high as 50% and 53.8% (Lp(a) excluded) as well as 65.7% and 64.9% (Lp(a) included) respectively.

摘要

我们对1266名健康人进行了血清脂蛋白(a)[Lp(a)]定量分析，并建立了不同年龄和性别人群的Lp(a)参考值。测定了心肌梗死（MI）幸存者、中风患者和原发性高血压患者的Lp(a)，并与年龄匹配的正常对照组进行比较。此外，还检测了胆固醇、甘油三酯、高密度脂蛋白胆固醇、载脂蛋白A1和载脂蛋白B。正常对照组和患者的Lp(a)浓度与其他脂质均无相关性。我们的结果表明，Lp(a)升高是MI和中风患者的独立危险因素。MI和中风患者脂质异常的总检出率（不包括Lp(a)）分别高达50%和53.8%，（包括Lp(a)）分别为65.7%和64.9%。