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新生大鼠睾丸组织同种异体移植:实验研究

[Testicular tissue homotransplantation of newborn rat: experimental study].

作者信息

Lu B

机构信息

Shiwan Hospital, Fushan, Guangdong.

出版信息

Zhonghua Wai Ke Za Zhi. 1993 Feb;31(2):91-3.

PMID:8223014
Abstract

32 newborn Sprague-Dawley rats were used as donors and 32 castrated male out-bred mature rats as recipients. The pieces of testes tissue were implanted subcutaneously in the bilateral hind legs. Two month follow-up showed that the grafts survived and increased in size. Serum testosterone levels of the recipients were higher than those of the castrated. They peaked and were close to the levels of the mature rats even 45 days after the implantation. Serum FSH, and, LH levels in the recipients were lower than those of the castrated. The mechanism of the newborn testes as an immuno-privileged donor is discussed.

摘要

32只新生Sprague-Dawley大鼠作为供体,32只去势的雄性远交系成熟大鼠作为受体。将睾丸组织块皮下植入双侧后腿。两个月的随访显示移植物存活且体积增大。受体的血清睾酮水平高于去势大鼠。植入后甚至45天,其水平达到峰值并接近成熟大鼠的水平。受体的血清促卵泡生成素(FSH)和促黄体生成素(LH)水平低于去势大鼠。本文讨论了新生睾丸作为免疫特惠供体的机制。

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