Wang Q H
Ruijin Hospital, Shanghai Second Medical University.
Zhonghua Wai Ke Za Zhi. 1993 Mar;31(3):148-52.
Using CD series monoclonal antibody indirect immune fluorescent assay and LDH enzyme-release assay, we investigated lymphocyte subsets and natural killer cells (NKC) activity in the peripheral blood of 30 patients with obstructive jaundice. The results showed that the percentage of CD3+, CD4+, B cells and that of CD8+ was high. The ratio of CD4/CD8 was low at the first 10 days of jaundice when the serum bilirubin level was less than 171 mumol/L. Our studies suggested that obstructive jaundice might cause depression and impairment of host cellular and humoral immunity. Further studies showed that impaired immune function of jaundiced patients returned to normal 30 days after the disappearance of the jaundice by external or internal biliary drainage. Immune function recovered 30 days after relief of biliary obstruction and external or internal biliary drainage. External or internal biliary drainage was useful in improving host immunity.
采用CD系列单克隆抗体间接免疫荧光法和乳酸脱氢酶释放法，我们对30例梗阻性黄疸患者外周血中的淋巴细胞亚群和自然杀伤细胞（NKC）活性进行了研究。结果显示，CD3⁺、CD4⁺、B细胞以及CD8⁺的百分比均较高。在黄疸出现的前10天，当血清胆红素水平低于171μmol/L时，CD4/CD8比值较低。我们的研究表明，梗阻性黄疸可能会导致宿主细胞免疫和体液免疫的抑制与损害。进一步的研究表明，通过外引流或内引流使黄疸消失30天后，黄疸患者受损的免疫功能恢复正常。在解除胆道梗阻并进行外引流或内引流30天后，免疫功能得以恢复。外引流或内引流有助于提高宿主免疫力。
