Nouvelot A, Dewailly P, Fruchart J C, Jaillard J, Sezille G
Nutr Metab. 1975;19(5-6):307-17.
The metabolism of three fat emulsions (Lipiphysan, Trive 1000, Intralipid) was compared when administered by intravenous route as complete parenteral nutrition in minipigs during 14 days. With Lipiphysan, an important accumulation of glycerides appeared in liver, spleen and lung whereas the phospholipids content of those tissues was unchanged. The three fat emulsions determined an increase of linoleic acid (18:2) percentages in glycerides and phospholipids of several tissues: liver, heart, lung, spleen and kidney. Moreover, at the level of phosphatidyl-ethanolamine (PE) in liver tissue, the three fat emulsions induced a decrease of some polyunsaturated fatty acids (C20 and C22) percentages. The observed differences in the amount of liver triglycerides between the three fat emulsions seem to be related with the removal mechanisms which appear to be dependent on each fat emulsion. In fact, all tissue lipid analyses showed an increase of 18:2 percentages which agree with an uptake of the different fat emulsions used. The decrease of polyunsaturated fatty acids percentages in PE might be due to an inhibition of elongationdesaturation system or a degradation of those fatty acids.
在小型猪中，以完全胃肠外营养的方式通过静脉途径给药14天时，比较了三种脂肪乳剂（力保肪宁、三酰甘油1000、英脱利匹特）的代谢情况。使用力保肪宁时，甘油酯在肝脏、脾脏和肺中出现重要蓄积，而这些组织中的磷脂含量未发生变化。这三种脂肪乳剂均使几种组织（肝脏、心脏、肺、脾脏和肾脏）的甘油酯和磷脂中亚油酸（18:2）百分比增加。此外，在肝组织中的磷脂酰乙醇胺（PE）水平上，这三种脂肪乳剂均导致一些多不饱和脂肪酸（C20和C22）百分比降低。三种脂肪乳剂之间观察到的肝脏甘油三酯量的差异似乎与清除机制有关，清除机制似乎取决于每种脂肪乳剂。事实上，所有组织脂质分析均显示18:2百分比增加，这与所使用的不同脂肪乳剂的摄取情况相符。PE中多不饱和脂肪酸百分比的降低可能是由于延长去饱和系统受到抑制或这些脂肪酸发生降解。
