Bax W A, Bos E, Saxena P R
Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Netherlands.
Eur J Pharmacol. 1993 Aug 3;239(1-3):267-8. doi: 10.1016/0014-2999(93)91010-k.
We investigated the effect of the ETA receptor antagonist, BQ-123 (0.1 and 1 microM), on contraction of the human isolated saphenous vein induced by endothelin-1 or sarafotoxin S6b. Contraction in response to endothelin-1 was not affected by BQ-123. In contrast, BQ-123 biphasically attenuated the contractions due to sarafotoxin S6b. These data indicate that (i) endothelin-1 induces contractions of the human saphenous vein via a non-ETA receptor and (ii) contractions in response to sarafotoxin S6b are mediated in part via a receptor different from the receptor mediating contraction due to endothelin-1.
我们研究了内皮素 A（ETA）受体拮抗剂 BQ - 123（0.1 微摩尔和 1 微摩尔）对内皮素 -1 或沙拉毒素 S6b 诱导的人离体隐静脉收缩的影响。BQ - 123 不影响内皮素 -1 引起的收缩。相反，BQ - 123 对沙拉毒素 S6b 引起的收缩有双相性减弱作用。这些数据表明：（i）内皮素 -1 通过非 ETA 受体诱导人隐静脉收缩；（ii）对沙拉毒素 S6b 的收缩反应部分是由不同于介导内皮素 -1 收缩的受体介导的。
