Baloh R W, Jacobson K M, Socotch T M
Department of Neurology, Reed Neurological Research Center, UCLA Medical Center 90024-1769.
Exp Brain Res. 1993;95(3):509-16. doi: 10.1007/BF00227144.
To determine age-related changes in oculomotor function we measured vestibuloocular (VOR), optokinetic (OKN), and visual-vestibular responses in a large group of normal subjects over the age of 75 years and compared the results with those from a group of young adults. Compared with the young subjects, older subjects had: (1) an amplitude-dependent decrease in VOR gain, (2) a shorter dominant VOR time constant, (3) a lower OKN slow-phase velocity saturation, and (4) a decreased ability to enhance and suppress the VOR with vision. These functional changes in older subjects are presumably secondary to well-documented, age-related changes in the sensory and neural elements of the visual-vestibulooculomotor pathways. They may be a contributory factor to the common complaints of dizziness and dysequilibrium in people over the age of 75 years.
为了确定眼动功能与年龄相关的变化，我们测量了一大组75岁以上正常受试者的前庭眼反射（VOR）、视动性眼震（OKN）和视-前庭反应，并将结果与一组年轻成年人的结果进行比较。与年轻受试者相比，老年受试者有：（1）VOR增益随振幅下降，（2）主导VOR时间常数缩短，（3）OKN慢相速度饱和度降低，（4）通过视觉增强和抑制VOR的能力下降。老年受试者的这些功能变化可能继发于视觉-前庭-眼动通路的感觉和神经元件中已充分记录的与年龄相关的变化。它们可能是导致75岁以上人群常见的头晕和平衡失调主诉的一个因素。
