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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Oikawa T, Ogura N, Akiba M, Abiko Y, Takiguchi H, Izumi H

Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Int J Biochem. 1993 Sep;25(9):1227-31. doi: 10.1016/0020-711x(93)90071-l.

Plasmin activity in the conditioned medium of Gin-1 cells, a human gingival fibroblast cell line, was stimulated by Porphyromonas endodontalis, a putative pathogen of oral submucous abscesses, in a time- and dose-dependent manner. 2. P. endodontalis stimulated the activity of plasminogen activator in both the conditioned medium and the cell lysate. The plasminogen activator in Gin-1 cells was approx. 50 kDa by zymography. 3. The conditioned medium of Gin-1 cells exposed to P. endodontalis stimulated the conversion of human serum prekallikrein to kallikrein. 4. These results suggested that P. endodontalis stimulates the plasminogen activator-plasmin system in Gin-1 cells, and that activated plasmin plays a role in the progress of periodontal tissue inflammation.

牙髓卟啉单胞菌是口腔黏膜下脓肿的一种潜在病原体，它能以时间和剂量依赖的方式刺激人牙龈成纤维细胞系Gin-1细胞条件培养基中的纤溶酶活性。2. 牙髓卟啉单胞菌刺激条件培养基和细胞裂解物中纤溶酶原激活剂的活性。通过酶谱分析，Gin-1细胞中的纤溶酶原激活剂约为50 kDa。3. 暴露于牙髓卟啉单胞菌的Gin-1细胞条件培养基刺激人血清前激肽释放酶转化为激肽释放酶。4. 这些结果表明，牙髓卟啉单胞菌刺激Gin-1细胞中的纤溶酶原激活剂-纤溶酶系统，并且激活的纤溶酶在牙周组织炎症进展中起作用。

Oikawa T, Ogura N, Akiba M, Abiko Y, Takiguchi H, Izumi H

Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Int J Biochem. 1993 Sep;25(9):1227-31. doi: 10.1016/0020-711x(93)90071-l.

Plasmin activity in the conditioned medium of Gin-1 cells, a human gingival fibroblast cell line, was stimulated by Porphyromonas endodontalis, a putative pathogen of oral submucous abscesses, in a time- and dose-dependent manner. 2. P. endodontalis stimulated the activity of plasminogen activator in both the conditioned medium and the cell lysate. The plasminogen activator in Gin-1 cells was approx. 50 kDa by zymography. 3. The conditioned medium of Gin-1 cells exposed to P. endodontalis stimulated the conversion of human serum prekallikrein to kallikrein. 4. These results suggested that P. endodontalis stimulates the plasminogen activator-plasmin system in Gin-1 cells, and that activated plasmin plays a role in the progress of periodontal tissue inflammation.

牙髓卟啉单胞菌是口腔黏膜下脓肿的一种潜在病原体，它能以时间和剂量依赖的方式刺激人牙龈成纤维细胞系Gin-1细胞条件培养基中的纤溶酶活性。2. 牙髓卟啉单胞菌刺激条件培养基和细胞裂解物中纤溶酶原激活剂的活性。通过酶谱分析，Gin-1细胞中的纤溶酶原激活剂约为50 kDa。3. 暴露于牙髓卟啉单胞菌的Gin-1细胞条件培养基刺激人血清前激肽释放酶转化为激肽释放酶。4. 这些结果表明，牙髓卟啉单胞菌刺激Gin-1细胞中的纤溶酶原激活剂-纤溶酶系统，并且激活的纤溶酶在牙周组织炎症进展中起作用。