Sumino Y, Kravetz D, Kanel G C, McHutchison J G, Reynolds T B
Division of Gastrointestinal and Liver Diseases, School of Medicine, University of Southern California, Los Angeles.
Gastroenterology. 1993 Nov;105(5):1477-82. doi: 10.1016/0016-5085(93)90154-5.
In an ultrasound pilot study of acute alcoholic hepatitis (AAH), parallel tubular structures within the liver subsegments were observed. Pulse-Doppler flowmetry revealed that these structures were formed by a dilated hepatic arterial branch and an adjacent portal venous branch. This finding was termed the "pseudoparallel channel sign" (PPCS). The aims of this study were to assess the significance of this sign and show the characteristic ultrasound findings of AAH.
PPCS was specifically searched for on ultrasonography by two physician operators in consecutive patients (77 AAH, 119 other alcoholic liver disease, 49 nonalcoholic liver disease, and 15 healthy patients).
PPCS was observed in 90% of patients with AAH and in 23% of patients with other alcoholic liver disease. This sign was not detected in nonalcoholic liver disease or healthy patients. Biopsy specimens were available in 100 patients, 51 of whom were patients with alcoholism. In those 51 patients, PPCS gave a sensitivity of 82%, a specificity of 87%, and an accuracy of 84% in diagnosing AAH. Patients with criteria of AAH had more segments involved with PPCS than patients without.
PPCS may be an important diagnostic finding in AAH.
在一项关于急性酒精性肝炎（AAH）的超声初步研究中，观察到肝亚段内存在平行管状结构。脉冲多普勒血流仪显示这些结构由扩张的肝动脉分支和相邻的门静脉分支形成。这一发现被称为“假性平行通道征”（PPCS）。本研究的目的是评估该征象的意义，并展示AAH的特征性超声表现。
两名医生操作者在连续的患者（77例AAH、119例其他酒精性肝病、49例非酒精性肝病和15例健康患者）中通过超声检查专门寻找PPCS。
90%的AAH患者观察到PPCS，23%的其他酒精性肝病患者观察到该征象。在非酒精性肝病患者或健康患者中未检测到该征象。100例患者可获得活检标本，其中51例为酒精中毒患者。在这51例患者中，PPCS诊断AAH的敏感性为82%，特异性为87%，准确性为84%。符合AAH标准的患者中出现PPCS的肝段比不符合的患者更多。
PPCS可能是AAH的一项重要诊断发现。
