SQ29852是一种新型的含膦酸基团的血管紧张素转换酶（ACE）抑制剂，对实验性高血压大鼠的慢性影响。
Chronic effects of SQ29,852, a new angiotensin converting enzyme (ACE) inhibitor with a phosphonic acid group, in experimental hypertensive rats.
作者信息
Kishi K, Ikeda M
机构信息
Department of Pharmacology, Jichi Medical School, Tochigi-ken, Japan.
出版信息
Gen Pharmacol. 1993 Jul;24(4):863-6. doi: 10.1016/0306-3623(93)90160-y.
PMID:8224740
Abstract
- Chronic effects on blood pressure of SQ29,852 administered daily for 21 consecutive days were compared to those of captopril and enalapril in spontaneously hypertensive (SHR) and two-kidney-one-clip renal hypertensive (CLIP) rats. 2. SQ29,852 showed significant chronic anti-hypertensive effects at 30 mg/kg in SHR and at 10 mg/kg in CLIP rats. Chronic anti-hypertensive effects of SQ29,852 were in-between those of enalapril and captopril. 3. Significant anti-hypertensive effects lasted in enalapril-treated SHR for 7 days after discontinuation of treatment, while only a tendency toward persistence of anti-hypertensive effects was noted in all animals treated with SQ29,852 and captopril.
摘要
- 将连续21天每日给予SQ29,852对血压的慢性影响与卡托普利和依那普利对自发性高血压（SHR）大鼠和二肾一夹肾性高血压（CLIP）大鼠的影响进行比较。2. SQ29,852在SHR大鼠中30mg/kg剂量时以及在CLIP大鼠中10mg/kg剂量时显示出显著的慢性抗高血压作用。SQ29,852的慢性抗高血压作用介于依那普利和卡托普利之间。3. 依那普利治疗的SHR大鼠在停药后7天仍有显著的抗高血压作用，而在用SQ29,852和卡托普利治疗的所有动物中，仅观察到抗高血压作用持续的一种趋势。
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