Nagasaka A, Yoshida S, Masunaga R, Kato S, Kotake M, Nakai A, Kawabe T, Tsujimura T, Inagaki A, Iwase K
Department of Internal Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Horm Metab Res. 1993 Aug;25(8):403-6. doi: 10.1055/s-2007-1002132.
The activity of DNA polymerase beta (beta-enzyme) in bovine and rat pituitary glands was remarkably higher in the anterior than in the posterior lobe. In sucrose gradient centrifugation, the activity in the anterior lobe of the bovine pituitary gland appeared at the sedimentation constant, 3.3 S, while that of rat pituitary gland appeared at 3.3 S, 7.3 S and 12 S, respectively. The activity in each fraction increased in the anterior lobes of rat pituitaries that were stimulated to release TSH by decreased thyroid hormone levels induced by an antithyroid drug. These results suggest that the activity of the beta-enzyme is high in the cells of the anterior lobe which are hyperfunctioned to produce pituitary thyreotrophic hormone and may be controlled by hormonal feedback regulation.
牛和大鼠垂体中DNA聚合酶β（β-酶）的活性在前叶显著高于后叶。在蔗糖梯度离心中，牛垂体前叶的活性出现在沉降常数3.3 S处，而大鼠垂体的活性分别出现在3.3 S、7.3 S和12 S处。在抗甲状腺药物诱导甲状腺激素水平降低从而刺激释放促甲状腺激素的大鼠垂体前叶中，各组分的活性增加。这些结果表明，β-酶的活性在功能亢进以产生垂体促甲状腺激素的前叶细胞中较高，并且可能受激素反馈调节的控制。
