Tehrani F T
Department of Electrical Engineering, California State University, Fullerton 92634.
IEEE Trans Biomed Eng. 1993 May;40(5):475-81. doi: 10.1109/10.243414.
A mathematical model of neonatal respiratory control is proposed which can be used to stimulate the system under different physiological conditions. The model consists of a continuous plant and a discrete controller. Included in the plant are lungs, body tissue, brain tissue, a cerebrospinal fluid compartment, and central and peripheral receptors. The effect of shunt in the lungs is included in the model and the lung volume and the dead space are time varying. The controller utilizes outputs from peripheral and central receptors to adjust the depth and rate of breathing and the effects of prematurity of peripheral receptors are included in the system. Hering-Breuer type reflexes are embodied in the controller to accomplish respiratory synchronization. The model is examined and its simulation results under test conditions in hypoxia and hypercapnia are presented.
提出了一种新生儿呼吸控制的数学模型，该模型可用于在不同生理条件下刺激该系统。该模型由一个连续的被控对象和一个离散的控制器组成。被控对象包括肺、身体组织、脑组织、脑脊液腔室以及中枢和外周感受器。模型中考虑了肺内分流的影响，并且肺容积和死腔是随时间变化的。控制器利用外周和中枢感受器的输出调节呼吸深度和频率，并且系统中考虑了外周感受器早产的影响。控制器中体现了黑林 - 布雷尔型反射以实现呼吸同步。对该模型进行了检验，并给出了其在缺氧和高碳酸血症测试条件下的仿真结果。
