Sardessai S R, Abraham M E, Mascarenhas J F
Department of Physiology, Goa Medical College, Bambolim.
Indian J Physiol Pharmacol. 1993 Apr;37(2):104-8.
The effect of 90 minute supine restraint or forced swim stress, on weights of various organs in sixty adult male albino rats was studied. One group of twenty rats served as control; second group of twenty was immobilized and third group of twenty was forced to swim in water at room temperature. The animals were studied for a period of 15 days. During this period, they were subjected to 90 minutes of stress everyday at the same time. Both the groups of stressed animals showed a statistically significant increase in weight of cerebrum, cerebellum, pituitary, thyroid, and adrenals. Testes and seminal vesicles showed no significant change in weight. There was an apparent increase in weight of liver after immobilization stress, and a statistically significant increase in its weight in forced swim group. Therefore, immobilization and forced swim stresses produce an increase in the weight of brain cerebrum and cerebellum, endocrine organs and liver.
研究了90分钟仰卧束缚或强迫游泳应激对60只成年雄性白化大鼠各种器官重量的影响。一组20只大鼠作为对照；第二组20只大鼠被固定，第三组20只大鼠被迫在室温水中游泳。对动物进行了15天的研究。在此期间，它们每天在同一时间承受90分钟的应激。两组应激动物的大脑、小脑、垂体、甲状腺和肾上腺重量均有统计学意义的增加。睾丸和精囊重量无显著变化。固定应激后肝脏重量明显增加，强迫游泳组肝脏重量有统计学意义的增加。因此，固定和强迫游泳应激会导致大脑、小脑、内分泌器官和肝脏重量增加。
