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与中毒性休克样综合征相关的两种化脓性链球菌菌株（M1型和M3型）的毒力取决于一个完整的类mry基因。

Virulence of two Streptococcus pyogenes strains (types M1 and M3) associated with toxic-shock-like syndrome depends on an intact mry-like gene.

作者信息

Perez-Casal J F, Dillon H F, Husmann L K, Graham B, Scott J R

机构信息

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.

出版信息

Infect Immun. 1993 Dec;61(12):5426-30. doi: 10.1128/iai.61.12.5426-5430.1993.

DOI:10.1128/iai.61.12.5426-5430.1993
PMID:8225619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281337/
Abstract

The major virulence factor of Streptococcus pyogenes, the M protein, is positively regulated at the transcriptional level by mry in the M type 6 strain studied. We show here that in two S. pyogenes strains isolated from cases of toxic-shock-like syndrome, a type M1 strain and a type M3 strain, an mry-like gene is also required for resistance to phagocytosis.

摘要

化脓性链球菌的主要毒力因子M蛋白，在所研究的M6型菌株中由mry在转录水平上正向调控。我们在此表明，在从中毒性休克样综合征病例中分离出的两株化脓性链球菌中，一株M1型菌株和一株M3型菌株，对吞噬作用的抗性也需要一个类似mry的基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/b8e6aae7f3ef/iai00024-0498-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/429541383237/iai00024-0497-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/706b54562d7f/iai00024-0498-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/b8e6aae7f3ef/iai00024-0498-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/429541383237/iai00024-0497-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/706b54562d7f/iai00024-0498-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb67/281337/b8e6aae7f3ef/iai00024-0498-b.jpg

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1
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Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci.鉴定一个调控M蛋白表达的基因，M蛋白是A组链球菌的主要毒力决定因素。
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