Harris R E, Zang E A, Anderson J I, Wynder E L
American Health Foundation, New York, NY 10017.
Int J Epidemiol. 1993 Aug;22(4):592-9. doi: 10.1093/ije/22.4.592.
Despite the extreme differences in the incidence of lung cancer between black and white Americans of each sex, little information is available on the sex-race-specific lung cancer risk due to tobacco use. In the current study, case-control data were examined for sex-race differences in the lung cancer risk associated with cigarette smoking. Results indicate that Kreyberg I lung cancers (squamous cell and oat cell carcinomas) are associated with heavier intensity of smoking than Kreyberg II lung cancer (adenocarcinomas and alveolar cell carcinomas); blacks are at higher risk than whites (relative risk = 1.8), and women are at higher risk than men for a given level of smoking (RR = 1.7). Our findings indicate the existence of important differences in the smoking-associated risk for lung cancer which depend upon sex, race, and histology.
尽管美国不同性别黑人和白人的肺癌发病率存在极大差异，但关于烟草使用导致的特定性别-种族肺癌风险的信息却很少。在当前研究中，对病例对照数据进行了检查，以探讨与吸烟相关的肺癌风险中的性别-种族差异。结果表明，克雷伯格I型肺癌（鳞状细胞癌和燕麦细胞癌）比克雷伯格II型肺癌（腺癌和肺泡细胞癌）与更高强度的吸烟相关；在给定的吸烟水平下，黑人比白人患癌风险更高（相对风险=1.8），女性比男性患癌风险更高（RR=1.7）。我们的研究结果表明，吸烟相关的肺癌风险存在重要差异，这取决于性别、种族和组织学类型。
