Uozumi J, Ueda T, Yasumasu T, Koikawa Y, Naito S, Kumazawa J, Sueishi K
Department of Urology, Kyushu University, Fukuoka, Japan.
Int Urol Nephrol. 1993;25(3):215-20.
Platinum (Pt) concentrations in the kidney and liver were determined in 12 autopsied cases following cisplatin treatment. The Pt level in the liver was generally higher than that in the kidney. Pt concentration in the liver showed a significant correlation with the total dose of cisplatin. However, no dose-dependent Pt accumulation was observed in the kidney. Kidney Pt levels were correlated with the doses of cisplatin injected within a 6-month period prior to the patient's death. It is suggested that the dose of cisplatin injected during a relatively short period before the patient's death affected the Pt concentration in the kidney.
对12例接受顺铂治疗后的尸检病例测定了肾脏和肝脏中的铂（Pt）浓度。肝脏中的铂水平通常高于肾脏。肝脏中的铂浓度与顺铂的总剂量呈显著相关性。然而，在肾脏中未观察到剂量依赖性的铂蓄积。肾脏中的铂水平与患者死亡前6个月内注射的顺铂剂量相关。提示在患者死亡前相对较短的时间内注射的顺铂剂量影响了肾脏中的铂浓度。
